| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 11-12-25 17:45 | FC Midtjylland | KRC Genk | 1:0 |
| 11-12-25 17:45 | PFC Ludogorets Razgrad | PAOK Salónica | 3:3 |
| 11-12-25 17:45 | FC Utrecht | Nottingham Forest | 1:2 |
| 11-12-25 17:45 | Ferencvaros Budapest | Glasgow Rangers | 2:1 |
| 11-12-25 17:45 | Young Boys Berna | OSC Lille | 1:0 |
| 11-12-25 17:45 | VfB Estugarda | Maccabi Tel Avive | 4:1 |
| 11-12-25 17:45 | Dínamo Zagreb | Real Betis Sevilla | 1:3 |
| 11-12-25 17:45 | SK Sturm Graz | Estrela Vermelha Belgrado | 0:1 |
| 11-12-25 17:45 | OGC Nice | Sporting Braga | 0:1 |
| 11-12-25 20:00 | FC Porto | Malmö FF | 2:1 |
| 11-12-25 20:00 | FC Basileia | Aston Villa | 1:2 |
| 11-12-25 20:00 | Olympique Lyon | Go Ahead Eagles Deventer | 2:1 |
| 11-12-25 20:00 | Panathinaikos Atenas | Viktoria Plzeň | 0:0 |
| 11-12-25 20:00 | SC Friburgo | FC Red Bull Salzburgo | 1:0 |
| 11-12-25 20:00 | FCSB Bukarest | Feyenoord Rotterdão | 4:3 |
| 11-12-25 20:00 | Celta Vigo | FC Bologna | 1:2 |
| 11-12-25 20:00 | Celtic Glasgow | AS Roma | 0:3 |
| 11-12-25 20:00 | Brann Bergen | Fenerbahce Istambul | 0:4 |